The beta-like globin gene cluster

Because of the existence of duplicated genes in this region, blind use of PIP is not recommended. However, the same tools can be applied in a customized manner to produce a similar kind of output. The plot shows some matches in the 5' and 3' flanks of the beta gene, and matches extending for over 16 kb upstream of the epsilon gene, in what is called the Locus Control Region. On the other hand, by first "zooming in" to the region before the epsilon gene (using the laj interface), one can get PIP output corresponding roughly to the first 20 kb of this plot.

Inspection of the plot suggests several hypotheses

Before long, this page may discuss these points in detail.