Hb Vicksburg beta75(E19)Leu->0
HEMATOLOGY Microcytosis and hypochromia in the heterozygote
ELECTROPHORESIS No separation observed
CHROMATOGRAPHY Hb X can be isolated on a DEAE-Sephadex column from the proband's lysate which contained Hb F and Hb A2 and no Hb A; Hb X moves like Hb A
STRUCTURE STUDIES Tryptic digestion of betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Not reported
OCCURRENCE Found in a 6-year-old Black male and presumably in his mother
OTHER INFORMATION Quantity in the heterozygote not reported; found in association with beta+-thal
1. Adams, J.G., III, Steinberg, M.H., Newman, M.V., Morrison, W.T., Benz, E.J., Jr., and Iyer, R.: Proc. Natl. Acad. Sci. USA, 78:469, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.