Hb Saint-Antoine beta74(E18)-beta75(E19) Gly-Leu->0
HEMATOLOGY Mild hemolytic anemia in the heterozygote
ELECTROPHORESIS No separation obtained at alkaline pH
STRUCTURE STUDIES pCMB; digestion of AE-betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Not reported
FUNCTION STUDIES Normal or nearly normal
STABILITY Slightly unstable
OCCURRENCE Found in a 25-year-old female of Mediterranean origin
1. Najman, A., Duhamel, G., Andre, R., Buc, H., Wajcman, H., Labie, D., and Schapira, G.: Nouv. Rev. Fr. d'Hematol., 13:803, 1973.
2. Wajcman, H., Labie, D., and Schapira, G.: Biochim. Biophys. Acta, 295:495, 1973.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.