Hb Niteroi | beta43(CD2)-beta45(CD4) Glu-Ser-Phe->0 |
---|---|
OR beta42(CD1)-beta44(CD3) Phe-Glu-Ser->0 |
HEMATOLOGY | Marked hemolytic anemia with reticulocytosis and Heinz bodies | ||
ELECTROPHORESIS | Not reported | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Not reported | ||
DNA ANALYSES | Not reported | ||
FUNCTION STUDIES | MetHb formation | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in a 26-year-old non-white Brazilian male, but not in his relatives | ||
OTHER INFORMATION | Splenectomy eliminated the need for transfusions (no detailed description of this interesting abnormality was found in the literature) |
REFERENCES | |||
1. | Praxedes, H. and Lehmann, H.: Abstract 400, Proceedings of the 14th International Congress of Hematology, Sao Paulo, Brazil, 1972. |