Hb Niteroi beta43(CD2)-beta45(CD4) Glu-Ser-Phe->0
OR beta42(CD1)-beta44(CD3) Phe-Glu-Ser->0
         
HEMATOLOGY Marked hemolytic anemia with reticulocytosis and Heinz bodies
ELECTROPHORESIS Not reported
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Not reported
DNA ANALYSES Not reported
FUNCTION STUDIES MetHb formation
STABILITY Unstable
OCCURRENCE Found in a 26-year-old non-white Brazilian male, but not in his relatives
OTHER INFORMATION Splenectomy eliminated the need for transfusions (no detailed description of this interesting abnormality was found in the literature)
       
REFERENCES
1. Praxedes, H. and Lehmann, H.: Abstract 400, Proceedings of the 14th International Congress of Hematology, Sao Paulo, Brazil, 1972.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.