Hb Coventry beta141(H19)Leu->0 (probably incorrect:
Suggested Leu->Hydroxyleu)
HEMATOLOGY No hematological abnormalities
ELECTROPHORESIS No separation of Hb X and Hb A
CHROMATOGRAPHY No separation reported
STRUCTURE STUDIES pCMB; tryptic digestion; separation of peptides by fingerprinting or HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported
FUNCTION STUDIES Increased oxygen affinity?
OCCURRENCE Found in several families and is widespread
OTHER INFORMATION The Hb Coventry anomaly always occurs in association with another unstable Hb (Hb Sydney, Hb Atlanta); it is likely incorrectly identified as a deletion of leucine at beta141; more likely is oxidation to hydroxyleucine [see Hb Atlanta; beta75 (E19)Leu->Pro]
1. Casey, R., Kynoch, P.A.M., Lang, A., Lehmann, H., Nozari, G., and Shinton, N.K.: Br. J. Haematol., 38:195, 1978.
2. Nozari, G., Rahbar, S., and Lehmann, H.: FEBS Lett., 95:88, 1978.
3. Brennan, S.O., Williamson, D., Symmans, W.A., and Carrell, R.W.: Hemoglobin, 7:303, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.