Hb Boyle Heights alpha6(A4)Asp->0
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves between Hb S and Hb F at alkaline pH, and with Hb A at acidic pH
CHROMATOGRAPHY Hb X and Hb A separate on a DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion of Hb X; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported
FUNCTION STUDIES Increased oxygen affinity
OCCURRENCE Found in members of a Mexican family
OTHER INFORMATION Quantity in the heterozygote 14%
1. Johnson, C.S., Schroeder, W.A., Shelton, J.B., and Shelton, J.R.: Hemoglobin, 7:125, 1983.
2. Zhao, W., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 14:637, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.