Hb F-Yamaguchi Agamma80(EF4)Asp->Asn; 75(E19)Ile->Thr
ELECTROPHORESIS Hb FX moves between Hb S and Hb C at alkaline pH
IEF About the same
CHROMATOGRAPHY Hb FX can be isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAT->AAT at codon 80
NOTES Found in Japanese newborn babies; quantity in the heterozygote 30-35%; its occurrence is associated with a Ggamma-thal
1. Fuyuno, K., Torigoe, T., Ohba, Y., Matsuoka, M., and Miyaji, T.: Hemoglobin, 5:139, 1981.
2. Nakatsuji, T., Ohba, Y., and Huisman, T.H.J.: Am. J. Hematol., 16:189, 1984.
3. Wada, Y., Fujita, T., Kidoguchi, K., and Hayashi, A.: Hum. Genet., 72:196, 1986.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.