Hb Zaïre His-Leu-Pro-Ala-Glu- inserted between
alpha116(GH4)Glu and alpha117(GH5)Phe
HEMATOLOGY Normal; slight microcytosis and hypochromia in the heterozygote
ELECTROPHORESIS Hb X moves faster than Hb A at alkaline pH
STRUCTURE STUDIES Tryptic digestion of AE-alphaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; frameshift is suggested
OCCURRENCE Found in a 36-year-old Zaïrian patient
OTHER INFORMATION Hb X 19% in the heterozygote; Hb X2 0.4%
1. Wajcman, H., Blouquit, Y., Vasseur, C., Le Querrec, A., Laniece, M., Melevendi, C., Rasore, A., and Galacteros, F.: Hum. Genet., 89:676, 1992.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.