Hb Parchman Two crossovers have been described:
a) deltabeta hybrid (delta through 12; beta from 22);
b) betadelta hybrid (beta from 22 through 50; delta from 87)
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves like Hb S at alkaline pH
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Gene mapping identified a deltabetadelta gene
OCCURRENCE Found in a Black male living in Mississippi
OTHER INFORMATION Quantity in the heterozygote 1.6%; found in a patient who was heterozygous for alpha-thal-2
1. Adams, J.G., III, Morrison, W.T., and Steinberg, M.H.: Science, 218:291, 1982.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.