Hb P-Congo | betadelta hybrid (beta through 22; delta from 116) |
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HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves to the position of Hb S at alkaline pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; it may be that the betadelta gene of Hb P-Congo is located between a delta and a beta gene; the hybrid gene may result from a non-homologous crossover between beta and delta genes | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in several families from the Congo | ||
OTHER INFORMATION | Found in combination with Hb S |
REFERENCES | |||
1. | Lehmann, H. and Charlesworth, D.: Biochem. J., 119:43, 1970. | ||
2. | Dherte, P., Lehmann, H., and Vandepitte, J.: Nature, 184:1133, 1975. |