Hb Miyada | betadelta hybrid (beta through 12; delta from 22) |
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HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves like Hb A2 at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis | ||
DNA ANALYSES | Gene mapping has identified this betadelta hybrid to be located between a delta and a beta gene; the hybrid gene results from a non-homologous crossover between beta and delta genes | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in a Japanese family and in a 24-year-old Italian male | ||
OTHER INFORMATION | Quantity in heterozygotes 17%; found in association with beta+-thal |
REFERENCES | |||
1. | Yanase, T., Hanada, M., Seita, M., Ohya, I., Ohta, Y., Imamura, T., Fujimura, T., Kawasaki, K., and Yamaoka, K.: Jpn. J. Hum. Genet., 13:40, 1968. | ||
2. | Ohta, Y., Yamaoka, K., Sumida, I., and Yanase, T.: Nature, 234:218, 1971. | ||
3. | Roberts, A.V., Clegg, J.B., Weatherall, D.J., and Ohta, Y.: Nature, 245:23, 1973. | ||
4. | Driscoll, M.C., Baird, M., Ohta, Y., and Bank, A.: Blood, 58:53a (Suppl. 1), 1981. |