Hb F-Onoda Ggamma146(HC3)His->Tyr
IEF Hb FX moves between Hb F and Hb A
CHAIN SEPARATION GgammaX = 35.9%; Ggamma = 33.5%; Agamma = 30.6%
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase A
DNA ANALYSES Not reported; presumed mutation CAC->TAC at codon 146
NOTES Found in a Japanese baby; Hb FX 26.4% of total Hb or 35% of total Hb F; increased oxygen affinity; normal Bohr effect and cooperativity

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.