Hb F-Cincinnati Ggamma41(C7)Phe->Ser
ELECTROPHORESIS Hb FX did not separate from Hb F at alkaline pH
IEF Hb FX did not separate from Hb F by IEF
CHAIN SEPARATION GgammaX = 29.5%; Ggamma = 37%; Agamma = 33.5%
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES A TTC->TCC mutation at codon 41
NOTES Found in a Caucasian newborn with cyanosis; baby became normal when Hb F disappeared after birth
1. Kholi-Kumar, M., Zwerdling, T., and Rucknagel, D.L.: Am. J. Hematol., 49:43, 1995.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.