Hb F-Austell Ggamma40(C6)Arg->Lys
ELECTROPHORESIS Hb FX moves slightly slower than Hb F at alkaline pH
IEF Not reported
CHROMATOGRAPHY Hb FX elutes slightly faster than Hb F in cation exchange HPLC
CHAIN SEPARATION AgammaT = 15%; Ggamma+GgammaX = 73.4%; Agamma = 11.6%
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation AGG->AAG at codon 40
NOTES Found in a Black newborn; baby was also heterozygous for the AgammaT chain; Hb FX 27% of total Hb
1. Kutlar, A., Kutlar, F., Wilson, J.B., Webber, B.B., Hu, H., and Huisman, T.H.J.: Hemoglobin, 12:409, 1988.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.