Hb Saverne	beta143 (-A); abnormal C-terminal sequence:
	(143)PRO-Ser-Ile-Thr-Lys-Leu-Ala-Phe-Leu-Leu-Ser-
	Asn-Phe-(156)Tyr-COOH (most likely sequence)

HEMATOLOGY		Heinz body hemolytic anemia in the heterozygote
ELECTROPHORESIS		Hb X moves faster than Hb A in IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed frameshift at codon beta143 (-A)
FUNCTION STUDIES		High oxygen affinity with low cooperativity
STABILITY		Unstable
OCCURRENCE		Found in a French female
OTHER INFORMATION		Quantity in the heterozygote 35%

REFERENCES
1.		Delanoe-Garin, J., Blouquit, Y., Arous, N., Kister, J., Poyart, C., North, M.L., Bardakdjian, J., Lacombe, C., Rosa, J., and Galacteros, F.: Hemoglobin, 12:337, 1988.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.