Hb A2-Zagreb delta125(H3)Gln->Glu
ELECTROPHORESIS Hb X moves between Hb A and Hb A2 at alkaline pH
IEF Not reported
CHROMATOGRAPHY Hb X elutes between Hb A2 and Hb A from a DEAE-cellulose column
STRUCTURE ANALYSIS Tryptic digestion of AE-deltaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSIS Not reported; presumed mutation CAA->GAA at codon 125
NOTES Found in a Yugoslavian (Croatian) family; occurred in association with a (deltabeta)o-thal
1. Juricic, D., Crepinko, I., Efremov, G.D., Lam, H. Webber, B.B., Headlee, M.G., and Huisman, T.H.J.: Hemoglobin, 7:443, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.