Hb A2-Manzanares delta121(GH4)Glu->Val
CONTACT External
ELECTROPHORESIS Hb X moves slower than Hb A2, about like Hb A2' (delta16)
IEF About the same
CHROMATOGRAPHY Hb X was isolated by DEAE-cellulose chromatography; Hb X is the first Hb fraction that is eluted
STRUCTURE ANALYSIS Tryptic digestion of AE-deltaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSIS Not reported; presumed mutation GAA->GTA at codon 121
NOTES Found in a Spanish family; variant is rather unstable
1. Romero Garcia, C., Navarro, J.L., Lam, H., Webber, B.B., Headlee, M.G., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 7:435, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.