Hb Ypsilanti (Ypsi) beta99(G1)Asp->Tyr
CONTACT Internal; alpha1beta2 contact
HEMATOLOGY Erythrocytosis in the heterozygote (PCV 0.46-0.63 l/l)
ELECTROPHORESIS Two components are present at alkaline pH: one moves in the position of Hb F, and the other moves between Hb A and Hb F
STRUCTURE STUDIES No details provided
DNA ANALYSES Not reported; presumed mutation GAT->TAT at codon 99
FUNCTION STUDIES Increased oxygen affinity
STABILITY Polymerization
OCCURRENCE Found in 17 members in three generations of a Black family
OTHER INFORMATION Quantity in the heterozygote: two components are present, one for 15% and the other for 25%
1. Rucknagel, D.L., Glynn, K.P., and Smith, J.R.: Clin. Res., 15:270, 1967.
2. Glynn, K.P., Penner, J.A., Smith, J.R., and Rucknagel, D.L.: Ann. Int. Med., 69: 769, 1968.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.