Hb Yoshizuka beta108(G10)Asn->Asp
CONTACT Central cavity; alpha1beta1 contact
HEMATOLOGY Slight anemia in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY Hb X can be separated by DEAE-Sephadex chromatography
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation AAC->GAC at codon 108
FUNCTION STUDIES Decreased oxygen affinity; normal cooperativity
OCCURRENCE Found in several members of a Japanese family
OTHER INFORMATION Quantity in heterozygotes ~50%
1. Imamura, T., Fujita, S., Ohta, Y., Hanada, M., and Yanase, T.: J. Clin. Invest., 48: 2341, 1969.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.