Hb Vaasa beta39(C5)Gln->Glu
CONTACT alpha1beta2 contact
HEMATOLOGY Mild hemolytic anemia in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves to a position slightly faster than Hb A
CHROMATOGRAPHY Hb X was isolated by DEAE-cellulose chromatography; Hb X elutes approximately as Hb F
STRUCTURE STUDIES Tryptic digestion of betaX chain; cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation CAG->GAG at codon 39
STABILITY Slightly unstable
OCCURRENCE Found in members of a Finnish family
OTHER INFORMATION Quantity in the heterozygote 33.1%
1. Kendall, A.G., ten Pas, A., Wilson, J.B., Cope, N., Bolch, K., and Huisman, T.H.J.: Hemoglobin, 1:292, 1977.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.