Hb Tyne beta5(A2)Pro->Ser
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS No separation by any known technique, including IEF
CHROMATOGRAPHY Hb X was detected by cation exchange HPLC; Hb X eluted close behind Hb A
STRUCTURE STUDIES Tryptic digestion; fingerprinting on a reversed phase column; amino acid analysis
DNA ANALYSES A CCT->TCT mutation at codon 5
STABILITY Slightly unstable
OCCURRENCE Found in two unrelated English citizens
OTHER INFORMATION None; quantity in the heterozygotes was not determined
1. Langdown, J.V., Williamson, D., Beresford, C.H., Gibb, I., Taylor, R., and Deacon-Smith, R.: Hemoglobin, 18:333, 1994.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.