Hb Tianshui beta39(C5)Gln->Arg
CONTACT alpha1beta2 contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X takes the position of Hb G and moves slightly faster than Hb S
STRUCTURE STUDIES Tryptic digestion of betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAG->CGG at codon 39
STABILITY Mildly unstable
OCCURRENCE Found in a Chinese (Han) family
OTHER INFORMATION Quantity in the heterozygote 41%
1. Li, H.J., Zhao, X.N., Li, H.W., Li, L., Liang, K.X., Wang, R.P., Chang, T.T., Wilson, J.B., Webber, B.B., and Huisman, T.H.J.: Hemoglobin, 14:569, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.