Hb Tampa beta79(EF3)Asp->Tyr
CONTACT External
HEMATOLOGY Normal in the heterozygote and the homozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves between Hb S and Hb F
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by reversed phase HPLC, fingerprinting, and cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAC->TAC at codon 79
OCCURRENCE Found in a 6-year-old Caucasian male; both parents have the trait and the child is homozygous for Hb X
OTHER INFORMATION Quantity in the heterozygote 33%
1. Johnson, M.H., Jue, D.L., Patchen, L.C., Hartwig, E.C., Schneider, M.J., and Moo-Penn, W.F.: Biochim. Biophys. Acta, 623:119, 1980.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.