Hb Shanghai beta131(H9)Gln->Pro
CONTACT Internal; alpha1beta1 contact
HEMATOLOGY Hemolytic anemia in the heterozygote; reticulocytosis
ELECTROPHORESIS No separation of Hb X and Hb A by routine analyses
CHROMATOGRAPHY No separation reported; the betaX and betaA chains separate by CM-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation CAG->CCG at codon 131
OCCURRENCE Found in members of a Chinese family
OTHER INFORMATION Quantity in the heterozygote ~35%
1. Zeng, Y.T., Ren, Z.R., Chen, M.J., Zhao, J.Q., Qiu, X.K., and Huang, S.Z.: Br. J. Haematol., 67:221, 1987.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.