Hb Rio Grande beta8(A5)Lys->Thr
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves between Hb A and Hb J on cellulose acetate at alkaline pH and between Hb A and Hb F on citrate agar at acidic pH
STRUCTURE STUDIES Tryptic digestion; fingerprinting; reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation AAG->ACG at codon 8
FUNCTION STUDIES Normal oxygen affinity, 2,3-DPG, and IHP
OCCURRENCE Found in members of a Mexican-American family
OTHER INFORMATION Quantity in the heterozygote 48.1%
1. Moo-Penn, W.F., Johnson, M.H., McGuffey, J.E., Jue, D.L., and Therrell, B.L., Jr.: Hemoglobin, 7:91, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.