Hb Rambam beta69(E13)Gly->Asp
         
ALSO KNOWN AS J-Cambridge
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES ryptic digestion; separation of peptides by fingerprinting; chymotryptic digestion; amino acid analysis; leucine amino peptidase
DNA ANALYSES Not reported; presumed mutation GGT->GAT at codon 69
FUNCTION STUDIES Not reported
STABILITY Normal
OCCURRENCE Found in a Bedouin family from Israel and an English family
OTHER INFORMATION Quantity in the heterozygote not reported
       
REFERENCES
1. Salomon, H., Tatarski, I., Dance, N., Huehns, E.R., and Shooter, E.M.: Israel J. Med. Sci., 1:836, 1965.
2. Sick, K., Beale, D., Irvine, D., Lehmann, H., Goodall, P.T., and MacDougall, S.: Biochim. Biophys. Acta, 140:231, 1967.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.