Hb Old Dominion beta143(H21)His->Tyr
CONTACT External; central cavity; 2,3-DPG binding site
HEMATOLOGY Normal in the heterozygote
CHROMATOGRAPHY Hb X moves faster than Hb A in cation exchange HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->TAC at codon 143
FUNCTION STUDIES Increased oxygen affinity
STABILITY Not reported
OCCURRENCE Found in a young diabetic male
OTHER INFORMATION Quantity in the heterozygote ~50%
1. Fairbanks, V., McCormick, D., Horn, A., Jones, R., Shih, D., Hoyer, J., Madden, B.J., and Kubik, K.: Blood, 86:647a (Suppl. 1), 1995.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.