Hb Okayama beta2(NA2)His->Gln
CONTACT 2,3-DPG binding site
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A can be separated by IEF; Hb X moves as Hb A1c
CHROMATOGRAPHY Hb X was isolated by cation exchange chromatography
STRUCTURE STUDIES Tryptic digestion; fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->CAA or CAG at codon 2
FUNCTION STUDIES Slight increase in oxygen affinity
OCCURRENCE Found in a diabetic Japanese male
OTHER INFORMATION Quantity in the heterozygote 47.4%
1. Harano, T., Harano, K., Shibata, S., Ueda, S., Mori, H., and Arimasa, N.: FEBS Lett., 156:20, 1983.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.