Hb Muskegon beta83(EF7)Gly->Arg
         
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves slower than Hb A at alkaline pH; slightly anodic to Hb S; Hb X moves between Hb S and Hb C at acidic pH
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; cyanogen bromide treatment; sequencing of CNBr peptide
DNA ANALYSES Not reported; presumed mutation GGC->CGC at codon 83
FUNCTION STUDIES Not reported
STABILITY Normal
OCCURRENCE Found in a few members of an American family
OTHER INFORMATION None; quantity in the heterozygote not reported
       
REFERENCES
1. Broxson, E.H., Hine, T.K., and Moo-Penn, W.F.: Hemoglobin, 17:85, 1993.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.