Hb Miyashiro beta23(B5)Val->Gly
CONTACT Internal
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A cannot be separated with routine electrophoretic procedures
CHROMATOGRAPHY No detailed information available
STRUCTURE STUDIES Fingerprinting; amino acid analysis; Dansyl-Edman degradation
DNA ANALYSES Not reported; presumed mutation GTT->GGT at codon 23
FUNCTION STUDIES Increased oxygen affinity; normal Bohr effect; decreased cooperativity
OCCURRENCE Found in members of a Japanese family
OTHER INFORMATION Quantity in the heterozygote estimated at 29-38%
1. Nakatsuji, T., Miwa, S., Ohba, Y., Hattori, Y., Miyaji, T., Miyata, H., Shinohara, T., Hori, T., and Takayama, J.: Hemoglobin, 5:653, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.