Hb Mississippi beta44(CD3)Ser->Cys
CONTACT Heme contact
HEMATOLOGY Normal in the heterozygote; Heinz body formation after oxidant stress
ELECTROPHORESIS More than one Hb zone might be present; three abnormal bands observed in globin chain electrophoresis
STRUCTURE STUDIES Tryptic digestion; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation TCC->TGC at codon 44
STABILITY Mildly unstable; formation of high molecular weight multi-mers (with other chains)
OCCURRENCE Found in a Chinese family
OTHER INFORMATION Occurs together with an undefined, presumably beta+-thal in the proband, causing a phenotype of thalassemia intermedia
1. Steinberg, M.H., Adams, J.G., III, Morrison, W.T., Pullen, D.J., Abney, R., Ibrahim, A., and Rieder, R.F.: J. Clin. Invest., 79:826, 1987.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.