Hb Mainz beta98(FG5)Val->Glu
CONTACT Internal; heme and alpha1beta2 contacts
HEMATOLOGY Severe hemolytic anemia
ELECTROPHORESIS Several slow moving bands observed at alkaline pH
CHROMATOGRAPHY Not reported; betaX and betaA appear to separate on a reversed phase HPLC column
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GTG->GAG at codon 98
OCCURRENCE Found in a 5-year-old German child; parents were not available for study
OTHER INFORMATION Hb X readily loses heme; the same is the case for Hb Nottingham
1. Wajcman, H., Behnken, L.J., Riou, J., and Galacteros, F.: Abstract 258, Br. J. Haematol., 87:66 (Suppl. 1), 1994.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.