Hb Lulu Island beta107(G9)Gly->Asp
CONTACT Internal
HEMATOLOGY Not available
ELECTROPHORESIS Hb X focuses slightly ahead of Hb A (IEF)
CHROMATOGRAPHY Hb X and Hb A partially separate by cation exchange HPLC; the betaX and betaA chains separate on a reversed phase HPLC column (elution order: betaX, betaA, delta, alpha)
DNA ANALYSES A GGC->GAC mutation at codon 107
FUNCTION STUDIES Normal oxygen affinity
OCCURRENCE Found in an East Indian female
OTHER INFORMATION The only carrier is compound heterozygous for Hb X and betao-thal (codon 15, TGG->TAG)
1. Gray, G.R., Manson, H.E., Gu, L-H., Leonova, J.Ye., and Huisman, T.H.J.: Am. J. Hematol., 50:26, 1995.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.