Hb Linköping	beta36(C2)Pro->Thr

ALSO KNOWN AS		Meilahti; Finlandia
CONTACT		alpha1beta2 contact
HEMATOLOGY		Erythrocytosis in the heterozygote
ELECTROPHORESIS		No separation of Hb X and Hb A observed at alkaline pH
CHROMATOGRAPHY		No separation observed by cation exchange HPLC; the betaX chain elutes very slowly from a reversed phase HPLC column (slower than the gamma chains)
STRUCTURE STUDIES		Mass spectrometry; amino acid sequence analysis
DNA ANALYSES		A CCT->ACT mutation at codon 36 (Ref. 3)
FUNCTION STUDIES		Increased oxygen affinity
STABILITY		Mildly unstable
OCCURRENCE		Found in several Finnish families and in a female of Dutch descent
OTHER INFORMATION		Quantity in the heterozygote about 30%

REFERENCES
1.		Jeppsson, J-O., Källman, L., Lindgren, G., and Fägerstam, L.G.: J. Chromatogr., 297:31, 1984.
2.		Jones, R.T., Head, C., Shih, M.F-C., Shih, D.T-B., Dana, B., Jones, M.B., and Koler, R.D.: Hemoglobin, 10:455, 1986.
3.		Ward, C.M., Fay, K.C., Brennan, J., Lowrey, I., and Blacklock, H.A.: Aust. N.Z. J. Med., 22:390, 1992.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.