Hb Linköping beta36(C2)Pro->Thr
ALSO KNOWN AS Meilahti; Finlandia
CONTACT alpha1beta2 contact
HEMATOLOGY Erythrocytosis in the heterozygote
ELECTROPHORESIS No separation of Hb X and Hb A observed at alkaline pH
CHROMATOGRAPHY No separation observed by cation exchange HPLC; the betaX chain elutes very slowly from a reversed phase HPLC column (slower than the gamma chains)
STRUCTURE STUDIES Mass spectrometry; amino acid sequence analysis
DNA ANALYSES A CCT->ACT mutation at codon 36 (Ref. 3)
FUNCTION STUDIES Increased oxygen affinity
STABILITY Mildly unstable
OCCURRENCE Found in several Finnish families and in a female of Dutch descent
OTHER INFORMATION Quantity in the heterozygote about 30%
1. Jeppsson, J-O., Källman, L., Lindgren, G., and Fägerstam, L.G.: J. Chromatogr., 297:31, 1984.
2. Jones, R.T., Head, C., Shih, M.F-C., Shih, D.T-B., Dana, B., Jones, M.B., and Koler, R.D.: Hemoglobin, 10:455, 1986.
3. Ward, C.M., Fay, K.C., Brennan, J., Lowrey, I., and Blacklock, H.A.: Aust. N.Z. J. Med., 22:390, 1992.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.