Hb Khartoum beta124(H2)Pro->Arg
         
CONTACT External; alpha1beta1 contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves like Hb S
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion of the AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CCA->CGA at codon 124
FUNCTION STUDIES Not reported
STABILITY Unstable
OCCURRENCE Found in a male from Khartoum; family was not available for study
OTHER INFORMATION Quantity in the heterozygote 30%
       
REFERENCES
1. Clegg, J.B., Weatherall, D.J., Wong, H.B., and Mustafa, D.: Nature, 22:379, 1969.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.