Hb Karlskoga beta21(B3)Asp->His
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; excellent separation by IEF
CHROMATOGRAPHY Hb X and Hb A can be separated by cation exchange HPLC
STRUCTURE STUDIES Proteolytic digestion; reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES A GAT->CAT mutation at codon 21
OCCURRENCE Found in a Swedish woman
OTHER INFORMATION Quantity in the heterozygote 39%
1. Landin, B.: Hemoglobin, 17:201, 1993.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.