Hb K-Woolwich	beta132(H10)Lys->Gln

CONTACT		External; near central cavity
HEMATOLOGY		Normal in heterozygotes and homozygotes
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves like Hb J; Hb X moves like Hb F at acidic pH
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of the peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation AAA->CAA at codon 132
FUNCTION STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in several Black families from the West Indies, Ghana, and the Ivory Coast
OTHER INFORMATION		Quantity in the heterozygote 28-40%; in the homozygous state 95.6%; found in combination with Hb S, Hb C, alpha-, and beta+-thal

REFERENCES
1.		Allan, N., Beale, D., Irvine, D., and Lehmann, H.: Nature, 208:658, 1965.
2.		Ringelhann, B., Konotey-Ahulu, F.I.D., Talapatra, N.C., Nkrumah, F.K., Wiltshire, B.G., and Lehmann, H.: Acta Haematol., 45:250, 1971.
3.		Cabannes, R., Renaud, R., Mauran, H., Pennors, H., Charlesworth, D., Price, B.G., and Lehmann, H.: Nouv. Rev. Fr. d'Hematol., 12:289, 1972.
4.		Cabannes, R., Amegnizin, P., Sangare, P., Arne, D., Casey, R., and Lehmann, H.: J. Med. Genet., 17:183, 1980.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.