Hb J-Lome beta59(E3)Lys->Asn
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate by standard techniques at alkaline pH and by IEF; Hb X moves faster than Hb A
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; CNBr; sequence by sequenator
DNA ANALYSES Not reported; presumed mutation AAG->AAC or AAT at codon 59
STABILITY About normal
OCCURRENCE Found in a family living in Lome, Togo
OTHER INFORMATION Quantity in heterozygotes ~50%; also found in association with HPFH
1. Wajcman, H., Amegnizin, K.P.E., Belkhodja, O., and Labie, D.: FEBS Lett., 84: 372, 1977.
2. Amegnizin, K.P.E., Pagnier, J., Wajcman, H., Lapoumeroulie, C., and Labie, D.: Hemoglobin, 3:87, 1979.
3. Prior, J.F., Raven, J.L., Wilson, J.B., Kutlar, A., Kutlar, F., and Huisman, T.H.J.: Hemoglobin, 13:79, 1989.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.