Hb J-Bangkok beta56(D7)Gly->Asp
ALSO KNOWN AS J-Meinung; J-Korat; J-Manado
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A can be separated at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; CNBr; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GGC->GAC at codon 56
OCCURRENCE Found in Thai, Indonesian, Black, and Chinese families
OTHER INFORMATION Quantity in the heterozygote 40-45%; also found in combination with Hb S
1. Clegg, J.B., Naughton, M.A., and Weatherall, D.J.: J. Mol. Biol., 19:91, 1966.
2. Blackwell, R.Q. and Liu, C-S.: Biochem. Biophys. Res. Commun., 24:732, 1966.
3. Pootrakul, S., Wasi, P., and Na-Nakorn, S.: Br. J. Haematol., 13:303, 1967.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.