Hb J-Altgeld Gardens beta92(F8)His->Asp
CONTACT Heme contact; proximal histidine
HEMATOLOGY Mild anemia in the proband who had Hb X-betao-thal
ELECTROPHORESIS Hb X moves faster than Hb A at alkaline pH
CHROMATOGRAPHY Not reported; the betaX and betaA chains readily separate by CM-cellulose chromatography (the Clegg method)
STRUCTURE STUDIES Tryptic digestion of the betaX chain; separation of peptides by fingerprinting; cation exchange chromatography; glycinamidation; amino acid analysis; formic acid
DNA ANALYSES Not reported; presumed mutation CAC->GAC at codon 92
FUNCTION STUDIES Normal oxygen affinity; cooperativity slightly decreased
STABILITY Mildly unstable
OCCURRENCE Found in a 21-year-old Black female and her son living in Chicago, Illinois, USA
OTHER INFORMATION Methemoglobinemia was absent
1. Adams, J.G., III, Przywara, K.P., Heller, P., and Shamsuddin, M.: Hemoglobin, 2:403, 1978.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.