Hb I-High Wycombe beta59(E3)Lys->Glu
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X is fast moving
CHROMATOGRAPHY Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation AAG->GAG at codon 59
OCCURRENCE Found in an English family and in a Australian family of German and Scottish descent
OTHER INFORMATION Quantity in the heterozygote ~45%
1. Boulton, F.E., Huntsman, R.G., Lehmann, H., Lorkin, P., and Romero Herrera, A.E.: Br. J. Haematol., 20:671, 1971.
2. Wilkinson, T., Como, P., Brock, P., Kronenburg, H., Trent, R.J.A., and Brennan, S.O.: Hemoglobin, 11:51, 1987.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.