Hb Hoshida beta43(CD2)Glu->Gln
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH and by IEF; Hb X is slightly faster than Hb S
CHROMATOGRAPHY Hb X and Hb A separate in anion exchange chromatography
STRUCTURE STUDIES Tryptic digestion; fingerprinting; reversed phase HPLC; chymotryptic and thermolysin digestion; amino acid analysis; sequencing
DNA ANALYSES A GAG->CAG mutation at codon 43 (Ref. 2)
OCCURRENCE Found in a Japanese family and in a Yugoslavian family
OTHER INFORMATION Quantity in the heterozygote 42-45%
1. Iuchi, I., Ueda, S., Hidaka, K., and Shibata, S.: Hemoglobin, 2:235, 1978.
2. Plaseska, D., Dimovski, A.J., Jankovic, L., Sukarova, E., Efremov, G.D., Gebauer, E., and Jerance, D.: Hemoglobin, 15:541, 1991.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.