Hb Hazebrouck beta38(C4)Thr->Pro
CONTACT Heme contact
HEMATOLOGY Hemolytic anemia with reticulocytosis; Heinz bodies
ELECTROPHORESIS Not detectable with standard methodology; Hb X moves slightly slower than Hb A by IEF
STRUCTURE STUDIES Tryptic digestion of betaX chain; fingerprinting and reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation ACC->CCC at codon 38
FUNCTION STUDIES Decreased oxygen affinity
STABILITY Mildly unstable
OCCURRENCE Observed in a French male
OTHER INFORMATION Quantity in the heterozygote estimated at 31%; hemichrome formation
1. Blouquit, Y., Delanoe-Garin, J., Lacombe, C., Arous, N., Cayre, Y., Peduzzi, J., Braconnier, F., and Galacteros, F.: FEBS Lett., 172, 155, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.