Hb Hamadan beta56(D7)Gly->Arg
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH (Hb X occupies the position of Hb S)
CHROMATOGRAPHY Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GGC->CGC at codon 56
OCCURRENCE Found in three members of an Iranian family, a French Caucasian family, and in four members of a family of Turkish descent
OTHER INFORMATION Quantity in the heterozygote 40%
1. Rahbar, S., Nowzari, G., Haydari, H., and Daneshmand, P.: Biochim. Biophys. Acta, 379:645, 1975.
2. Dinçol, G., Aksoy, M., Dinçol, K., Kutlar, A., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 8:423, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.