Hb G-Siriraj beta7(A4)Glu->Lys
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves between Hb S and Hb F (Tris buffer) and between Hb A2 and Hb S (barbiturate buffer) on paper at alkaline pH; Hb X moves between Hb E and Hb S on starch gel at alkaline pH, and as Hb C on citrate agar at acidic pH
CHROMATOGRAPHY Hb X and Hb A can be separated by cation and anion exchange HPLC
STRUCTURE STUDIES Tryptic digestion; fingerprinting; amino acid analysis; carboxypeptidase B used to determine the C-terminal amino acid of peptide betaT-1
DNA ANALYSES Not reported; presumed mutation GAG->AAG at codon 7
STABILITY Not reported
OCCURRENCE Found in a few Thai and Chinese families
OTHER INFORMATION Quantity in heterozygotes 33-40%; the variant has been found in combination with beta-thal and in a homozygote (Ref. 3)
1. Tuchinda, S., Beale, D., and Lehmann, H.; Br. Med. J., 1:1583, 1965.
2. Blackwell, R.Q., Liu, C-S., and Wang, C-L.: Vox Sang., 23:433, 1972.
3. Zeng, Y. and Huang, S.; Acta Genet. Sin., 6:155, 1979.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.