Hb G-Copenhagen beta47(CD6)Asp->Asn
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH (Hb X moves slightly ahead of Hb S) but not at acidic pH
CHROMATOGRAPHY Excellent separation of Hb X and Hb A by cation exchange HPLC and DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion; peptides separated by reversed phase HPLC or by fingerprinting; amino acid analysis; chymotryptic digestion; sequencing
DNA ANALYSES Not reported; presumed mutation GAT->AAT at codon 47
OCCURRENCE Found in a Danish, a Sicilian, and a Black family
OTHER INFORMATION Quantity in the heterozygote 46-48%
1. Sick, K., Beale, D., Irvine, D., Lehmann, H., Goodall, P.T., and MacDougall, S.: Biochim. Biophys. Acta, 140:231, 1967.
2. Schiliro, G., Musumeci, S., Russo, A., Marino, S., Russo, G., Marinucci, M., Fontanarosa, P.P., and Tentori, L.: Hemoglobin, 5:195, 1981.
3. Chen, S.S., Wilson, J.B., Webber, B.B., Kutlar, A., and Huisman, T.H.J.: Hemoglobin, 9:405, 1985.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.