Hb Detroit beta95(FG2)Lys->Asn
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A; no separation at acidic pH
CHROMATOGRAPHY Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES Tryptic digestion; fingerprinting; cation exchange chromatography; amino acid analysis; sequence by Sequenator; HPLC
DNA ANALYSES Not reported; presumed mutation AAG->AAC or AAT at codon 95
FUNCTION STUDIES Normal oxygen affinity
OCCURRENCE Found in a 30-year-old Indian female living in the USA
OTHER INFORMATION Quantity in the heterozygote ~48%
1. Moo-Penn, W.F., Schneider, R.G., Andrian, S., and Das, D.K.: Biochim. Biophys. Acta, 536:283, 1978.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.