Hb D-Ibadan beta87(F3)Thr->Lys
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH (Hb X has the mobility of Hb S); at acidic pH Hb X moves slightly slower than Hb A but much faster than Hb S
CHROMATOGRAPHY Hb X and Hb A separate in both cation and anion exchange HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin; sequencing
DNA ANALYSES Not reported; presumed mutation ACA->AAA at codon 87
OCCURRENCE Found in a few Nigerian families and in a Black male in the USA
OTHER INFORMATION Quantity in the heterozygote 41%; found in combination with Hb S and with deltabeta-thal
1. Watson-Williams, E.J., Beale, D., Irvine, D., and Lehmann, H.: Nature, 205:1273, 1965.
2. Falusi, A.G., Ogunmola, G.B., and Esan, G.J.F.: Clin. Res., 25:338A, 1977.
3. Rucknagel, D.L.: Hemoglobin, 3:77, 1979.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.