Hb Bologna beta61(E5)Lys->Met
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation AAG->ATG at codon 61
FUNCTION STUDIES Decreased oxygen affinity; normal cooperativity and Bohr effect
OCCURRENCE Found in a few members of a North Italian family
OTHER INFORMATION Quantity in heterozygotes 47-48.5%; found in association with betao-thal
1. Marinucci, M., Giuliani, A., Maffi, D., Massa, A., Giampaolo, A., Mavilio, F., Zannotti, M., and Tentori, L.: Biochim. Biophys. Acta, 668:209, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.