Hb Baylor beta81(EF5)Leu->Arg
CONTACT 2,3-DPG pocket
HEMATOLOGY Hemolytic process present but with relatively high Hb and red cell values; Heinz bodies
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves slightly faster than Hb S; at acidic pH Hb X moves between Hb A and Hb S
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES Tryptic digestion; cation exchange chromatography; glycin-amidation; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CTC->CGC at codon 81
FUNCTION STUDIES Increased oxygen affinity; decreased cooperativity; normal Bohr effect
OCCURRENCE Found in a Caucasian male of Italian-Irish parentage
OTHER INFORMATION Quantity in the heterozygote ~22%
1. Schneider, R.G., Hettig, R.A., Bilunos, M., and Brimhall, B.: Hemoglobin, 1:85, 1977.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.